R. Vlădăreanu * , Roxana Bohîlţea **
* Conf dr Radu Vlădăreanu – Universitatea de Medicină şi Farmacie “Carol Davila” Bucureşti, Clinica de Obstetrică-Ginecologie Elias
** Prep. univ. dr Roxana Bohîlţea – Universitatea de Medicină şi Farmacie “Carol Davila” Bucureşti, Clinica de Obstetrică-Ginecologie Elias
Abstract
Preterm birth is a major contributor to perinatal mor ity and morbidity and the prevention should be one oftal the major aims of antenatal care, but unfortunately, the medical therapy is still controversial. Calcium channel blocker maintenance therapy is usually used after an episode of threatened preterm labour in an attempt to prevent the onset of further preterm contractions. During last two years, systematic meta-analysis reviewing the efficacy of these agents versus beta-mimetics on acute faze, concluded that calcium channel blockers are more efficient in prolonging pregnancies for more than 7 days, with reduced materno-fetal effects and neo-natal mortality. Nifedipine is an effective tocolytic agent with a relatively low cost, with a facile administration route, an immedi ate availability and a low incidence of side effects. Well designed randomized trials of sufficient size with relevant outcomes are still required.