Andreea Cristina Stoian 1, A. Cupşa 1, Florentina Dumitrescu 1, Elena Ştefan 2, L. Giubelan 1, Irina Niculescu 1, Cristina Iocu 2, I. Diaconescu 1, Livia Dragonu 1, Maria Marinescu 2
1 Craiova University of Medicine and Pharmacy
2 Craiova Clinical Hospital for Infectious Diseases “Victor Babeş”
Abstract
Objective: This study aimed to determine and analyze the antibiotic sensitivity of Klebsiella pneumoniae strains isolated from urine cultures. Material and methods: Retrospective, comparative study, performed within the Craiova Clinical Hospital for Infectious Diseases “Victor Babeş”, determining the evolution of the chemosensitivity of uropathogenic Klebsiella pneumoniae in urinary tract infections, during 2000-2004 and 2005-2008. Results: During 2000-2004, we identified 161 pathologic urine samples bacteriologically positive for Klebsiella pneumoniae (15,01% of the total positive urocultures) and we analyzed them through antibiogram testing. Between 2005-2008, we identified 127 pathological bacteriologically positive urine samples (13.23% of all positive urine cultures). The rates of susceptibility to antibiotics tested in the first period of the study were: 33.7% for amoxicillin/clavulanic acid, 77.15% for aztreonam, 89.46% for cefoperazone-sulbactam, 85% for ceftazidime, 84% for amikacin, 79.91% for gentamicin, 74.13% for ofloxacin, 84.25% for norfloxacin, 67.16% for nalidixic acid, 62.71% for colistin and 96.59% for meropenem. During the second studied period, the rates of susceptibility to antibiotics were: 22.22% for amoxicillin-clavulanic acid, 62.65% for aztreonam, 62.51% for cefoperazone-sulbactam, 76% for ceftazidime, 84.31% for amikacin, 70% for gentamicin, 69,69% for ofloxacin, 65.82% for norfloxacin, 57.14% for nalidixic acid, 80.35% for colistin and 95.96% for meropenem. Conclusions: Increased susceptibility of K. pneumoniae to meropenem and certain aminoglycosides (amikacin) is maintained. We noticed an increasing trend in the sensitivity to colistin and a declining trend in that to quinolones and certain IIIrd generation cephalosporins (ceftazidime, cefoperazone-sulbactam).