Gabriela Cioca 1, Minerva Boitan 1, Ioan Maniţiu 1, Radu Cojan 2, Liviu Safta 3, Radu Trâmbiţaş 4
1 Faculty of Medicine „Victor Papilian”, University „Lucian Blaga” Sibiu
2 Emergency County Clinical Hospital Sibiu, Cardiology Department,
3 University of Medicine „Iuliu Haţieganu” Cluj-Napoca
4 University „Babeş-Bolyai”, Faculty of Mathematics and Informatics
Abstract
The endothelial function is a “barometer” of the health of the cardiovascular system, and its quantification in patients suff ering from a cardiovascular disorder, particularly arterial hypertension, represents a useful method for the evaluation of cardiovascular risk, of the severity of the disease and a useful method for the quantifi cation of the eff ectiveness of several therapeutic strategies. We have performed a comparative clinical study, open, randomized, non-interventional on parallel groups of subjects with essential arterial hypertension degrees 1, 2 and 3 for the comparison of the effi ciency of the angiotensin II conversion enzyme inhibitors (IECA) and the receptor antagonists for angiotensin II (ARA) on the endothelial dysfunction evaluated through the fl ow-mediated vasodilatation (FMD). Comparing the average of the FMD increase after 12 months of treatment for the two treatments we concluded that there are no statistically significant differences.