Lidia Nica Udangiu 1, Denise Buda 2
1 Professor, University “Titu Maiorescu
2 Senior psychiatrist, Psychiatry Hospital “Prof. Dr. Al. Obregia” Bucharest
Abstract
Depressive disorders are considered to be clinical entities frequently seen in medical practice, causing a very high level of disease burden and are expected to show a rising trend during the coming 20 years. Simptoms of depressive episode in both recurrent depressive disorder and bipolar affective disorder are similar. Despite of theese similarities, recent studies show that depressive episode who appears in both disorders, is different regarding etiology, course and adjacent neurochemical processes. The therapeutic plan used for the treatment of depression usually combines an antidepressant with a benzodiazepine. The current study investigates the therapeutic efficiency of clonazepam versus diazepam in association with paroxetine used to treat the depressive episode – Major Depressive Disorder.