Jeana-Rodica Radu *
* Jeana-Rodica Radu – Prof. Univ. Dr. U.M.F. “Carol Davila” – Catedra Alergologie
Abstract
IG-mediated allergic disorders with a persistent clinical picture, represent some of the most common allergic sufferings, being frequently associated with the athopy. Signs of frequency, evolutive severity and their consequences on the costs of treatments and on the quality of the sick men ‘s life, affect the person, family and society. The real reason of these disorders, of specific inflammatory nature, motivates the persistancy of the symptomatology, which can be modulated as intensity through major influences, some with increased incidency in the cold season. Respiratory viroses (especially with: rhinoviroses, coronoviruses, v. influenzae, v. parainfluenzae, respiratory sincital virus or adenoviroses) exert a respiratory tropism and interfere completely in the agression of the aerial tracts. The viral multiplication through cytotoxicity and invading of epithelial cells, the inflammation marked by the release of mediators, cytokines, celular adhesion molecules, as well as possible sensibilization lgE mediated virus specific, contributes greatly to the exacebations on the cold season of the respiratory allergies. In this context, H-1 antihistaminics, reverse agonists of the specific receiver for histamine, interfere in controlling or modulating these processes. Besides the antihistaminic effects, reverse agonists of the specific receiver for histamine exert anti-allergic and anti-inflammatory actions on different levels of the allergic cascade and reduce the expression of celular adhesion molecule s (ICAM1) and ARN messanger for ICAM1, which serve as receiver for 90% of the rhinoviruses. This way, H-1 antihistaminics has not only curative effects but also profilactive ones in order to stop/ improve the exacerbations of the respiratory allergies lgE – mediated, in the cold season.