Dănescu Ilenuţa 1, Voicu V.A. 2, Macovei R. 1, 3, Caragea Genica 4, Forje Mărgărita 4, Ionică M. 5
1 ICU II Toxicology, Clinical Emergency Hospital Bucharest
2 Romanian Academy
3 University of Medicine and Pharmacy “Carol Davila”
4 Military Medical Research Center
5 University “Politehnica” Bucharest, Optoelectronic Research Center
Abstract
Rhabdomyolysis is a clinical and biochemical syndrome with potentially fatal result of an aggression that destroys the integrity of the sarcolemma of skeletal muscle cells, leading to release of toxic cellular components in the extracellular space and movement. In acute poisoning several proposed direct and indirect mechanisms have been observed. . The study of these mechanisms leads to a correct diagnosis and rapid toxic rhabdomyolysis, preventing major complications. We present six clinical cases of acute poisoning with ethylene glycol, buformin, carbon monoxide, doxylamine, venlafaxine and of exotic fish sting. Due to the early identification and maintainance of a high index of suspicion, most patients with rhabdomyolysis in acute intoxication have an excellent prognosis if they are rapidly and correctly treated.