Ioana Bădicuț, Smaranda Botea, Cristina Țenea, Monica Popoiu, Marcela Furtună
Institutul Național de Boli Infecțioase “Prof. Dr. Matei Balș București
Abstract
The bacteremic and septicemic risk conditio ns have increased over the last decades. The etiological spectrum of these nosological entities has greatly diversified, the classic pathogen occurrences have decreased and those of opportunistic microorganisms have increased; these microorgan isms are very diversified and are a normal presence of the tegument, in the digestive system, saprophyte of air-microflora. The sensitivity spectrum to antibiotics has narrowed significantly with corresponding adjustments over the therapeutic decisions. Ob jective: characterization of microbiological spectrum of systemic infections, interpreting of isolate resistance to microbial agents Method and material: during January-December 2005, 3234 blood cultures have been processed using the BacTI Alert system. The positive samples have been identified using the MicroScan and MiniApi systems. Sensitivity testing has been conducted using semi-quantitative and/or quan titative techniques as per CLSI guidelines. The statistical interpretation of data has been done using the WhonetS.3 and Excel programs. Results: a total of 197 real positive blood cultures have been identified (6.09%) of which 2 were fungi and 195 bacterial from which Gram-pozitive cocci (67%) and Gram-negative bacilli (31,97%). Conclusions: re-emergence of Gram-positive cocci as a cause of blood infections with high incidence of S. aureus (20,40%) and equal incidence of coagulase-negative staphylococci with E. coli (18,87%). Increased resistance to antibiotics for MRSE (54,1% ), MRSA (50%), E. coli (18%) and K. pneumoniae (64%) ESBL producing.