Victoria Aramă *, R. Vlădăreanu **
* Dr. Vidoria Aramă, asistent universitar; Clinica I Boli Infețioase Colentina, UMF “Carol Davila” București
** Dr. Radu Vlădăreanu, șef de lucrări, Clinica Obstretică Ginecologie, Spitalul de Urgență “Sf. Pantelim” UMF “Carol Davila” București
Abstract
Pregnancy modifies antibiotic pharmacokinetics resulting in serum concentrations lower than in non-preg nant women. This would lead (theoretically) to the increase of drug doses. The beta-lactamins are safe in pregnancy. These antibiotics should be used against urinary infections, listeriosis, syphilis, endometritis, etc. Macrolides may be used in pregnancy: erythromycin against Chlamydia infections and spiramycine in maternofetal toxoplasmosis. Aminoglycosides, tetracyclines and quinolones are contraindicated in pregnancy. Metronidazole, sulfamides and trimetoprim shoud be avoided during the first and last trimesters of pregnancy. The pyrimetha mine-sulfadiazine combination is the most effective treatment of maternofetal toxoplasmosis. Active tuberculosis during the first trimester of preganancy should be treated by associating isoniazid and ehambutol. Rifampycin should be avoided during pregnancy.